Perricone MD – Neuropeptide Night Cream 75ml

$148.00
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  • Twenty years of research have yielded our most advanced and comprehensive night treatment cream.

  • Ultra-rich overnight cream designed to visibly improve firmness, deep wrinkles, and overall smoothness as you sleep.

  • Powered by advanced neuropeptides that target dynamic wrinkles and help relax visible tension patterns in the skin.

  • Strengthens hydration, improves elasticity, and supports a more resilient moisture barrier overnight.

  • Leaves skin looking refreshed, lifted, and well-rested by morning, supporting both the complexion and emotional wellbeing through a replenishing nighttime ritual.

  • How to use: Massage onto cleansed face and neck in the evening using a gentle upward motion. Wait until fully absorbed.

Water/Aqua/Eau, Glycerin, Isononyl Isononanoate, Pentaerythrityl Tetraethylhexanoate, Cetearyl Alcohol, Butyrospermum Parkii (Shea) Butter, C12-20 Acid PEG-8 Ester, Dimethyl Isosorbide, C10-18 Triglycerides, Isodecyl Salicylate, Butylene Glycol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Squalane, C12-15 Alkyl Benzoate, Dimethicone, Polymethyl Methacrylate, Dimethyl MEA, Acetyl Hexapeptide-8, Pentapeptide-18, Tetrapeptide-21, Dipeptide-2, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Tyrosine, Tocopheryl Acetate, Dipotassium Glycyrrhizate, Hesperidin Methyl Chalcone, Ceramide NG, Fructose, Allantoin, Trehalose, Maltose, Glucose, Sodium Hyaluronate, Citric Acid, Sodium Hydroxide, Disodium EDTA, Sodium Chloride, Steareth-20, Polysorbate 60, Caprylyl Glycol, Tribehenin, Coco-Glucoside, Pentylene Glycol, Hexylene Glycol, Urea, PEG-10 Rapeseed Sterol, Sodium Lactate, Sodium PCA, Phenoxyethanol, Potassium Sorbate, Fragrance/Parfum, Linalool, Limonene

This formula uses high-activity neuropeptides that influence the skin–nerve interface by reducing visible tension, improving cellular communication, and helping reorganize the extracellular matrix during the skin’s natural repair cycle. Ingredients like Acetyl Hexapeptide-8 and Pentapeptide-18 modulate neurotransmitter release involved in expression wrinkles, helping soften dynamic lines. Additional peptides such as Palmitoyl Tetrapeptide-7 provide anti-inflammatory support that indirectly reduces neurogenic stress. Together, they offer a cumulative neurocosmetic effect that enhances firmness, smoothness, and stress-related aging markers.

Key Neurocosmetic Ingredients

A neurotransmitter-modulating peptide that reduces muscle contraction intensity by interfering with the SNARE complex. It helps soften expression wrinkles by calming nerve-mediated micro-tension in the skin.

A neuropeptide analogue that decreases the release of acetylcholine in targeted areas, visibly reducing dynamic wrinkle depth. Works synergistically with Acetyl Hexapeptide-8 for stronger smoothing effects.

A neuro-signaling modulator involved in lymphatic support and circulation. Helps improve puffiness and reduces stagnation often associated with neurosensory overload.

Reduces neurogenic and inflammatory cytokines such as IL-6, helping calm skin reactivity and improve repair processes.